Good Delivery Can Take You Everywhere
Aposense Molecular Nano-Motors (MNM) The First Gene Delivery Platform, Energized By The Internal Membrane Electrical Field.
Aposense is an Israeli biopharmaceutical company, specializing in development of novel drugs, utilizing membrane electrical forces, for trans-membrane of macromolecule drugs, mainly siRNA. The Company has full capacity research facilities and scientific leadership, headed by Professor Ilan Ziv and Professor Roger Kornberg, Nobel Prize Laureate, 2006.
These Molecular Nano-Motors (MNMs) are the core of our Technology
The MNMs are pharmaceutically-compatible, small-molecule chemical moieties (MW≈800 Daltons), capable of moving within the core of cell membranes, energized by the internal electric field. We can efficiently control the Intra-membrane movement of the MNMs pharmacologically, and respectively, enable and control the related trans-membrane transport of a genetic cargo drug linked to the MNM, with delivery into practically any cell type. Furthermore, our delivery system comprises an innovative detachment moiety, selectively activated upon entry into cells, releasing and liberating the intact macro-molecule drug in the cytoplasm, to exert its biological action, while the MNM is excreted through the urine or bile.