Good Delivery Can Take You Everywhere
Aposense Molecular Nano-Motors (MNM) The First Gene Delivery Platform, Energized By The Internal Membrane Electrical Field.
Aposense is a highly innovative Israeli biotechnology company with full capacity research facilities and scientific leadership, headed by the Professor Roger D Kornberg, Nobel Prize Laureate, 2006. Aposense developed a universal platform entitled Molecular Nano-Motors (MNMs) for the delivery of genetic drugs, such as siRNA, into cells based on a novel mechanism of action, utilizing membrane electrical forces.
These Molecular Nano-Motors (MNMs) are the core of our Technology
Aposense’s MNMs are pharmaceutically-compatible, small-molecule chemical moieties (MW≈800 Daltons), capable of moving within the core of cell membranes, energized by the internal electric field. We can efficiently control the Intra-membrane movement of the MNMs pharmacologically, and respectively, enable and control the related trans-membrane transport of a genetic cargo drug linked to the MNM, with delivery into practically any cell type. Furthermore, our delivery system comprises an innovative detachment moiety, selectively activated upon entry into cells, releasing and liberating the intact macro-molecule drug in the cytoplasm, to exert its biological action, while the MNM is excreted through the urine or bile.