Hearing Disorders

The hearing disorders field represents a huge unmet medical need as it affects ~15% of the world’s adult population with no approved therapeutics. The physiological structure and conditions in the inner ear are favourable for our technology. To date we have shown that the Molecular Nano-Motors conjugate can effectively reach the auditory nerve fibers which resides in the inner ear. We are pursuing multiple hearing loss conditions. We anticipate moving our first clinical candidates hearing loss into clinical development in 2023

	siRNA-MNM conjugate	Naked siRNA
Median of the cochlea			OHC: Outer hair cells IHC: Inner hair cells SC: supporting cells ANF: Auditory nerve fibers
Base of the cochlea
Performed at Cilcare, France

	siRNA-MNM conjugate
Median of the cochlea
Base of the cochlea
	Naked siRNA
Median of the cochlea
Base of the cochlea
OHC: Outer hair cells IHC: Inner hair cells SC: supporting cells ANF: Auditory nerve fibers
Performed at Cilcare, France