The hearing disorders field represents a huge unmet medical need as it affects ~15% of the world’s adult population with no approved therapeutics. The physiological structure and conditions in the inner ear are favourable for our technology. To date we have shown that the Molecular Nano-Motors conjugate can effectively reach the auditory nerve fibers which resides in the inner ear. We are pursuing multiple hearing loss conditions. We anticipate moving our first clinical candidates hearing loss into clinical development in 2023
siRNA-MNM conjugate | Naked siRNA | ||
Median of the cochlea | ![]() | ![]() | OHC: Outer hair cells IHC: Inner hair cells SC: supporting cells ANF: Auditory nerve fibers |
Base of the cochlea | ![]() | ![]() | |
Performed at Cilcare, France |
siRNA-MNM conjugate | ||
Median of the cochlea | ![]() | |
Base of the cochlea | ![]() | |
Naked siRNA | ||
Median of the cochlea | ![]() | |
Base of the cochlea | ![]() | |
OHC: Outer hair cells IHC: Inner hair cells SC: supporting cells ANF: Auditory nerve fibers | ||
Performed at Cilcare, France |