Hearing Disorders

The hearing disorders field represents a huge unmet medical need as it affects ~15% of the world’s adult population with no approved therapeutics. The physiological structure and conditions in the inner ear are favourable for our technology. To date we have shown that the Molecular Nano-Motors conjugate can effectively reach the auditory nerve fibers which resides in the inner ear. We are pursuing multiple hearing loss conditions. We anticipate moving our first clinical candidates hearing loss into clinical development in 2023

siRNA-MNM conjugateNaked siRNA
Median of the cochleaOHC: Outer hair cells
IHC: Inner hair cells
SC: supporting cells
ANF: Auditory nerve fibers
Base of the cochlea
Performed at Cilcare, France
siRNA-MNM conjugate
Median of the cochlea
Base of the cochlea
Naked siRNA
Median of the cochlea
Base of the cochlea
OHC: Outer hair cells
IHC: Inner hair cells
SC: supporting cells
ANF: Auditory nerve fibers
Performed at Cilcare, France